Open Forum Infectious Diseases, April 7, 2018
Paixao ES, Leong WY, Rodrigues LC, Wilder-Smith A
To investigate to what extent asymptomatic vs symptomatic prenatal Zika virus infections contribute to birth defects, the authors identified 3 prospective and 8 retrospective studies. The ratio varied greatly in the retrospective studies, most likely due to recruitment and recall bias. The prospective studies revealed a ratio of 1:1 for asymptomatic vs symptomatic maternal Zika infections resulting in adverse fetal outcomes.