Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected
Stephanie L. Cumberworth†, Jennifer A. Barrie†, Madeleine E. Cunningham, Daniely Paulino Gomes de Figueiredo, Verena Schultz, Adrian J. Wilder-Smith, Benjamin Brennan, Lindomar J. Pena, Rafael Freitas de Oliveira França, Christopher Linington, Susan C. Barnett, Hugh J. Willison, Alain Kohl† and Julia M. Edgar† - Acta Neuropathologica Communications Neuroscience of Disease, June 23, 2017
The recent global outbreak of Zika virus (ZIKV) infection has been linked to severe neurological disorders affecting the peripheral and central nervous systems (PNS and CNS, respectively). Here CNS and PNS myelinating cultures from wild type and Ifnar1 knockout mice are used to examine neuronal and glial tropism and short-term consequences of direct infection with a Brazilian variant of ZIKV.
NEURO-ZIKA: Neurological Manifestations of Zika
Defining the spectrum of neurological diseases associated with Zika virus (ZIKV) infection, in both the central nervous system (CNS) and peripheral nervous system (PNS) of adults and children.
WEAR: Wearable Aedes Repellent Technologies
To protect pregnant women, novel, wash-in detergent formulations and long-lasting plastic technologies containing repellents for the treatment of clothing and other wearable repellent technologies are being developed using new microencapsulation techniques.
Investigating Vaccines in Antibody Dependent Enhancement
Identifying the major T-cell epitopes and cross reactive B-cell epitopes on ZIKV and assessing the role of flavivirus antibodies in protective and pathogenic immunity following ZIKV through antibody dependent enhancement (ADE).