Human stem cell-derived hepatocyte-like cells support Zika virus replication and provide a relevant model to assess the efficacy of potential antivirals
Tricot et al. - PLOS ONE, December 19, 2018
High levels of ZIKV RNA have been detected in mice and non-human primates in organs other than the brain, such as the liver, and closely related flaviviruses, the dengue and yellow fever viruses, are known to cause hepatitis. This study examines ZIKV infection of human hepatocytes.
NEURO-ZIKA: Neurological Manifestations of Zika
Defining the spectrum of neurological diseases associated with Zika virus (ZIKV) infection, in both the central nervous system (CNS) and peripheral nervous system (PNS) of adults and children.
WEAR: Wearable Aedes Repellent Technologies
To protect pregnant women, novel, wash-in detergent formulations and long-lasting plastic technologies containing repellents for the treatment of clothing and other wearable repellent technologies are being developed using new microencapsulation techniques.
Investigating Vaccines in Antibody Dependent Enhancement
Identifying the major T-cell epitopes and cross reactive B-cell epitopes on ZIKV and assessing the role of flavivirus antibodies in protective and pathogenic immunity following ZIKV through antibody dependent enhancement (ADE).