Extensive Genetic Differentiation between Homomorphic Sex Chromosomes in the Mosquito Vector, Aedes aegypti
Albin Fontaine, Igor Filipović, Thanyalak Fansiri, Ary A. Hoffmann, Changde Cheng, Mark Kirkpatrick, Gordana Rašić, and Louis Lambrechts - Genome Biology and Evolution, September 2017
Mechanisms and evolutionary dynamics of sex-determination systems are of particular interest in insect vectors of human pathogens like mosquitoes because novel control strategies aim to convert pathogen-transmitting females into nonbiting males, or rely on accurate sexing for the release of sterile males. This study’s results lay a new foundation for the mapping and population genomic studies in Aedes aegypti, and for the control strategies that rely on accurate sexing and sex reversal in this important mosquito vector.
NEURO-ZIKA: Neurological Manifestations of Zika
Defining the spectrum of neurological diseases associated with Zika virus (ZIKV) infection, in both the central nervous system (CNS) and peripheral nervous system (PNS) of adults and children.
WEAR: Wearable Aedes Repellent Technologies
To protect pregnant women, novel, wash-in detergent formulations and long-lasting plastic technologies containing repellents for the treatment of clothing and other wearable repellent technologies are being developed using new microencapsulation techniques.
Investigating Vaccines in Antibody Dependent Enhancement
Identifying the major T-cell epitopes and cross reactive B-cell epitopes on ZIKV and assessing the role of flavivirus antibodies in protective and pathogenic immunity following ZIKV through antibody dependent enhancement (ADE).