News

Important call for action: Chikungunya Outbreak

Researchers in Brazil want to share that there have been 40 confirmed deaths from Chikungunya in Fortaleza. This is a significant increase in both mortality and the severity of the disease. The Fortaleza research team are part of the REDe ... Read more

Launch of WHO Toolkit

June 21, 2017 - Zika virus is associated with severe neurological complications, particularly congenital Zika virus syndrome and Guillain Barré syndrome. The associated complications have a marked impact on the people affected and their communities, including both physical and mental ... Read more

Featured Publication

Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected

Stephanie L. Cumberworth†, Jennifer A. Barrie†, Madeleine E. Cunningham, Daniely Paulino Gomes de Figueiredo, Verena Schultz, Adrian J. Wilder-Smith, Benjamin Brennan, Lindomar J. Pena, Rafael Freitas de Oliveira França, Christopher Linington, Susan C. Barnett, Hugh J. Willison, Alain Kohl† and Julia M. Edgar† - Acta Neuropathologica Communications Neuroscience of Disease, June 23, 2017
†Contributed equally

The recent global outbreak of Zika virus (ZIKV) infection has been linked to severe neurological disorders affecting the peripheral and central nervous systems (PNS and CNS, respectively). Here CNS and PNS myelinating cultures from wild type and Ifnar1 knockout mice are used to examine neuronal and glial tropism and short-term consequences of direct infection with a Brazilian variant of ZIKV.

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Research Focus

NEURO-ZIKA: Neurological Manifestations of Zika

Defining the spectrum of neurological diseases associated with Zika virus (ZIKV) infection, in both the central nervous system (CNS) and peripheral nervous system (PNS) of adults and children.

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WEAR: Wearable Aedes Repellent Technologies

To protect pregnant women, novel, wash-in detergent formulations and long-lasting plastic technologies containing repellents for the treatment of clothing and other wearable repellent technologies are being developed using new microencapsulation techniques.

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Investigating Vaccines in Antibody Dependent Enhancement

Identifying the major T-cell epitopes and cross reactive B-cell epitopes on ZIKV and assessing the role of flavivirus antibodies in protective and pathogenic immunity following ZIKV through antibody dependent enhancement (ADE).

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