ZikaPLAN takes a comprehensive approach to tackling the Zika threat, encompassing epidemiological surveillance, clinical studies, the development of innovative diagnostic tools and control strategies, in addition to education and knowledge-sharing.
ZikaPLAN’s work is organized along two main axes: the objectives of addressing Zika and preparing for beyond Zika.
The aim is to tackle key knowledge gaps in the recent Zika outbreak and to define future needs, by:
- determining the attack rate and full clinical spectrum of Congenital Zika Syndrome
- defining the spectrum of neurological diseases associated with Zika virus (ZIKV) infection, in the central nervous system (CNS) and peripheral nervous system (PNS) of adults and children (excluding neonates)
- investigating the extent of and factors associated with sexual transmission of Zika in human and animal models
- discovering and characterising the mechanistic pathways of ZIKV infection in the pathogenesis of CNS and PNS injury
- developing and validating tools for the diagnosis, surveillance and research on ZIKV
- identifying the major T-cell epitopes & cross-reactive B-cell epitopes
- assessing the evolution of the ZIKV outbreak in Brazil
Preparing for beyond Zika
The aim is to build a sustainable Latin-American EID Preparedness and Response capacity, by:
- establishing mathematical models to inform public health policies
- developing novel wash-in detergent formulations and long-lasting plastic technologies
- establishing alongside ZIKAlliance and ZIKAction, a Latin-American and Caribbean network, REDe, to address the broader issue of building local capacity to prepare for and rapidly launch a large-scale research response to emerging infectious disease threats.
ZikaPLAN’s is contributing to the development of an inter-epidemic research plan, policy recommendations, training, research networks and dissemination strategies designed to permanently strengthen local capacities, beyond the four years of the project. The three consortia have common bodies for the global management of scientific programs, communication, and ethical, regulatory and legal issues.
- MERG: Unravelling Congenital Zika Syndrome
- NEURO-ZIKA: Neurological Manifestations of Zika
- Non-vector Transmission of ZIKV
- NEURO-ZIKA: Pathogenesis
- Platform for Diagnostics Innovation and Evaluation
- INVADE: Investigating Vaccines in Antibody Dependent Enhancement
- Viral Fitness: Current Versus Historical ZIKV
- Disease Burden and Risk Assessment
- Mathematical Modelling to Inform Public Health Policies
- WEAR: Wearable Aedes Repellent Technologies
- ZIKA Collaborative Establishment of a Latin American Preparedness Network (PLAN)
- Dissemination and Communication
- Consortium Coordination
- Zika Data Share: Harmonisation of Data and a Roadmap Towards Data Sharing
- ZIKA-COLLAB: Intra-consortium Collaboration
ZikaPLAN Working Groups (WP)