Key Results & Achievements

Data sharing in real time

Over the period of four years, representatives from each of the three consortia have collaborated closely to produce a Joint Statistical Analysis Plan for analysing the harmonized data from the cohort studies published in the BMJ (Ades et al., BMJ Open).

In addition, joint governance boards were created for data sharing. The role of these committees is to ensure the responsible handling and protection of sensitive data as well as the scientific integrity of the joint analyses.

It is anticipated that the cohort data collected in WP1 will be shared in the future via an individual participant data meta-analysis of cohort data from across Brazil and another from across the world, organized by the World Health Organization.

The protocol of the WHO IPD-MA analysis plan was published in BMJ Open: ‘Understanding the relation between Zika virus infection during pregnancy and adverse fetal, infant and child outcomes: a protocol for a systematic review and individual participant data meta-analysis of longitudinal studies of pregnant women and their infants and children.’ Wilder-Smith A, Wei Y, Araújo TVB, et al. BMJ Open (doi:10.1136/bmjopen-2018-026092).

Participating Organisations

Group leader: Prof. Ricardo Ximenes, Universidade de Pernambuco

  • Umeå University
  • London School of Hygiene & Tropical Medicine
  • University of Oxford