Nature Reviews Neurology, March 1, 2021

Nowshin Papri, Zhahirul Islam, Sonja E. Leonhard, Quazi D. Mohammad, Hubert P. Endtz, Bart C. Jacobs


Key points

  • The considerable regional variation evident in the epidemiology, subtypes and management of Guillain–Barré syndrome (GBS) can be explained by geography, population demographics, environmental and economic factors.
  • Poor hygiene and sanitation along with frequent exposure to pathogens render populations in low-income and middle-income countries (LMIC) prone to outbreaks of infectious diseases that can trigger GBS.
  • High rates of adverse outcomes and mortality in LMIC can be explained by insufficient health-care infrastructure leading to diagnostic delays and lack of available and affordable treatment.
  • Owing to differences in disease severity, clinical presentation and patient management between high-income countries (HIC) and LMIC, existing models to predict the outcome of GBS must be validated for LMIC.
  • New and low-cost treatment strategies for GBS need to be developed along with improved access to integrative rehabilitation services in LMIC.

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