Nature Reviews Neurology, March 1, 2021
Nowshin Papri, Zhahirul Islam, Sonja E. Leonhard, Quazi D. Mohammad, Hubert P. Endtz, Bart C. Jacobs
- The considerable regional variation evident in the epidemiology, subtypes and management of Guillain–Barré syndrome (GBS) can be explained by geography, population demographics, environmental and economic factors.
- Poor hygiene and sanitation along with frequent exposure to pathogens render populations in low-income and middle-income countries (LMIC) prone to outbreaks of infectious diseases that can trigger GBS.
- High rates of adverse outcomes and mortality in LMIC can be explained by insufficient health-care infrastructure leading to diagnostic delays and lack of available and affordable treatment.
- Owing to differences in disease severity, clinical presentation and patient management between high-income countries (HIC) and LMIC, existing models to predict the outcome of GBS must be validated for LMIC.
- New and low-cost treatment strategies for GBS need to be developed along with improved access to integrative rehabilitation services in LMIC.