Science Direct, Antiviral Research, September 2017
Kristina Lanko, Kristel Eggemont, Abdulsamie Patel, Suzanne Kaptein, Leen Delang, Catherine M. Verfaillie, Johan Neyts
Abstract
Infections with the Zika virus (ZIKV) are responsible for congenital abnormalities and neurological disorders. It is demonstrated here that ZIKV productively infects three types of human iPSC (induced pluripotent stem cells)-derived cells from the neural lineage, i.e. cortical and motor neurons as well as astrocytes. These results highlight the need to assess the potential antiviral activity of novel ZIKV inhibitors in stem cell derived neuronal cultures.