BMJ Open, December 12, 2020

Joan K Morris, Helen Dolk, Pablo Durán, Ieda Maria Orioli


To summarise the occurrence of congenital Zika syndrome (CZS) in Latin America and the Caribbean from 2015 to 2017 using two outcome measures derived from infectious disease surveillance reports and to assess the completeness of these reports.

Surveillance study.

Pan American Health Organization (PAHO)/WHO epidemiology reports on confirmed and suspected Zika virus infection and cases of CZS.

Populations of 47 countries in the South and Central Americas, Mexico and the Caribbean.

Primary and secondary outcome measures
The number of CZS cases per 1000 births (using 2016–2017 births as a denominator) and the number of CZS cases per 1000 births in women with Zika virus infection during pregnancy.

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